Similarly, the nuclear accumulation of Histone Deacetylase 4 (HDAC4), an epigenetic regulator implicated in several neurodegenerative disorders—including stroke, PD, AD, and ataxia telangiectasia—also disrupts dendrite architecture of mature neurons by negatively affecting VEGFD expression [252–257]. The gene discussed is HDAC4; the disease is Parkinson disease.