Moreover, we have previously reported that tofogliflozin inhibits renal damage in KKAy/Ta mice, obese and type 2 diabetic animals (Ishibashi et al. 2016 , 2016), but the effects of SGLT2is on the AGE-RAGE axis in the kidneys of type 2 diabetic animals remain unclear. This evidence concerns the gene RENBP and type 2 diabetes mellitus.