AGER and metabolic disease: The formation and accumulation of AGEs has progressed under a physiological aging process, especially under chronic hyperglycemic and inflammatory conditions, and engagement of the receptor for AGEs (RAGE) with AGEs elicits oxidative stress generation and evokes inflammatory reactions, thereby being involved in various aging-related cardiorenal and metabolic disorders (Yamagishi and Matsui 2019; Ramasamy et al. 2011; Genuth et al. 2005; Thomas et al. 2005; Yamagishi 2012).