Given the active involvement of AGE-RAGE axis in numerous kinds of aging-related complications in diabetes (Yamagishi and Matsui 2019; Ramasamy et al. 2011; Genuth et al. 2005; Thomas et al. 2005; Yamagishi 2012), SGLT2is may work as anti-AGEs agents. The gene discussed is RENBP; the disease is diabetes mellitus.