ANGPT1 and acute respiratory distress syndrome: Patients with a reactive phenotype had high plasma levels of markers of inflammation, coagulation, and endothelial activation (IL-6, IFN-γ, angiopoietin 1/2, and plasminogen activator inhibitor-1), with increased ICU mortality.140 The pathogenesis of ARDS differs between patients with pulmonary(ARDSp) and extrapulmonary(ARDSexp) lung injury, which is related to the identification of biomarker-driven subphenotypes.