Formation of NETs is essential in immunothrombosis, and it relies on the CLEC5A-TLR2 activation in CARDS as extremely low level of NETs is detected in neutrophils with both CLEC5A and TLR2 ablation.77 While in bacterial infection-induced ARDS, CXCL2-CXCR2 signaling activation of neutrophils is more significant,78 because CXCL2 is more sensitive in response to molecules of bacterial origin. The gene discussed is CLEC5A; the disease is bacterial infectious disease.