COL22A1 and leiomyoma: The most significant variant was rs56897532 (OR 0.78, 95% CI 0.72–0.85, p = 5.39 × 10−9) in COL22A1 (intergenic) and is a novel gene association with fibroids (Fig. 5, Supplementary Data 3d, Supplementary Fig. 6k).