In colorectal cancer, coactivator-associated arginine methyltransferase CARM1 methylates arginine 339 (R339) of ACSL4, promotes the binding of RNF25 to ACSL4 and its ubiquitination, inhibits ferroptosis of tumor cells, and effectively attenuates ferroptosis-related cancer immunotherapy [39]. Here, RNF25 is linked to cancer.