KLF13 and obesity due to melanocortin 4 receptor deficiency: One transcription factor that showed up several times across “pro” and “anti” CpG enrichment analyses was KLF13. Mutations in this gene underlie a form of congenital heart disease [45] and cg07814318, a CpG site annotated to KLF13, is associated with both obesity and obesity-related traits [46].