CheekAge outcompeted every other clock tested by significantly associating with a total of 33 different disease and health variables, including human immunodeficiency virus, major depressive disorder, psychological trauma, prediabetes, body mass index, non-alcoholic fatty liver disease, pulmonary fibrosis, exposure to the chemical endocrine disruptor PBB-153, and various cancers and tumors. Here, CLOCK is linked to prediabetes syndrome.