Similarly, scRNA-seq analysis of CD8+ T cells from these patients found a lower ISR score in kidney CD8+ TRM cells from patients with ANCA-GN compared to kidney CD8+ TRM cells from healthy controls (Extended Data Fig. 8b,c), indicating increased CD8+ TRM cell activation in kidneys from patients with ANCA-GN. The gene discussed is CD8A; the disease is ganglioneuroma.