CXCL5 and cancer: To study the role of cancer-derived CXCL5 in the growth of M1-CM-treated spheroids, we deleted Cxcl5 in Panc02 cells using CRISPR/Cas9 (Supplementary Fig. 2A) and performed a 3D spheroid-in-Matrigel culture of wild-type (WT) or Cxcl5−/− Panc02 cells with or without M0- or M1-CM.