It was reported that, fructose consumption having been implicated in the etiology of hyperglycemia, hyperinsulinemia & insulin resistance in adult rats40 .This is in line with our study where the rats fed HF or HF/HFAT diets showed higher levels of fasting blood glucose, insulin and HOMA-IR than HFAT consuming rats. The gene discussed is INS; the disease is Hyperinsulinemia.