Sirius red and Masson staining of liver sections (Fig. 8b, c), HYP levels (Fig. 8d) and fibrotic gene expression in liver tissue (Fig. 8e) indicated that MSCs significantly ameliorated liver fibrosis in Fstl1+/− mice after FSTL1 addition, whereas FSTL1 + PF4136409 addition in Fstl1-deficient mice imparted no further functional benefit after cell infusion. Here, PHEX is linked to Hepatic fibrosis.