PIK3CA and neoplasm: Phosphatidylinositol (PtdIns) metabolism regulates signaling and membrane trafficking, crucial for tumor/TME interactions5–9, is enriched in druggable proteins5,6, contains a known proto-oncogene (PIK3CA) and tumor suppressor (PTEN)5,6, and the PI3K/AKT pathway is activated in PDAC10, with additional Ptdlns kinases implicated in this cancer11,12.