AP2S1 and neoplasm: To assess the effect of these changes on the transcriptome, we performed total RNA sequencing on triplicate cultures and five independent tumors derived from CFPAC-1, PANC-1, and BXPC-3 cells, representative of the gradual increase in tumor growth upon AP2 loss, with and without AP2S1 inactivation (Figs. 5a and S5a).