CSF2 and Alzheimer disease: Of note, using high-dose GM-CSF/M-CSF (50 ng/ml) instead of AD blood plasma (with physiological concentrations of GM-CSF ( < 1 to 10 pg/ml) and M-CSF (20–1000 pg/ml)24), maximized and aligned the yield of well-differentiated MDMs derived from NEO and AD Mo, concealing the age signature of MDM differentiation (Supplementary Fig. 6a–c).