Furthermore, in a model of oxygen-induced retinopathy, PAI-1 expression was upregulated during active angiogenesis, where at the same time PAI-1 null mice exhibited a significant reduction (53%) in retinal angiogenesis compared to wild-type mice, emphasizing PAI-1’s importance in retinal angiogenesis process [32]. The gene discussed is SERPINE1; the disease is retinal disorder.