Supporting the potential involvement of these integrins, in an analysis of scRNA-Seq datasets in sham and AKI mice intercellular adhesion molecule-1 (ICAM1), a ligand for LFA-1 or Mac-1, was found upregulated in lung endothelium on day 1 after AKI (Figure 4A). The gene discussed is ITGB2; the disease is acute kidney injury.