SPARC and early-onset autosomal dominant Alzheimer disease: ASGR1, primarily found in myeloid cells and the liver, is an emerging therapeutic target for hypercholesterolemia due to its role in decreasing lipid levels.[63, 64, 65] SMOC1, part of the SPARC (secreted protein acidic and rich in cysteine) family, plays diverse roles in tissue development and cell–matrix interactions[66] and is often implicated in Alzheimer's disease,[67] further indicating its potential involvement in chronic pain progression.