Examining plasma adipokines and adipose health, we found that leptin was significantly increased with obesity, and tended to be lowered with BZA/CE (Figure 3A), again primarily driven by a reduction in leptin in the obese BZA/CE-treated rats, reflecting the BZA/CE-associated reduction in adipose mass as described above. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.