It is worth noting that the wild-type mice had a normal adrenal stress response at all stages of sepsis, with no “insufficient GC relative to an increased demand” or “inadequate cellular corticosteroid activity for the severity of the patient’s critical illness.” Therefore, the ΔGC detected by the ACTH test is inappropriate for the diagnosis of adrenal insufficiency under septic conditions and may incorrectly diagnose RAI or CIRCI. Here, POMC is linked to Adrenal insufficiency.