We found that 24 of the 54 specific proteins (detected in >70% of the samples), including IFN-γ, CCL8, IL-6, IL-8, and other inflammatory factors, were differentially expressed between SLE patients with NP symptoms (NPSLE) and those without NP symptoms (non-NPSLE) (P < 0.05, Supplemental Figure 11B). The gene discussed is IL6; the disease is systemic lupus erythematosus.