CSF1R and systemic lupus erythematosus: In addition, depletion of microglia with PLX5622, a selective inhibitor of colony-stimulating factor 1 receptor (CSF1R), maintained dendritic integrity and alleviated depressive behavior in MRL/lpr mice (Supplemental Figure 6, H–K), suggesting that microglia-mediated engulfment contributes to synapse loss in lupus mice.