The strong correlation between liver 68 Ga-FAPI-46 uptake and the histological stage of liver fibrosis suggests that FAPI-PET may play an important role in the non-invasive staging of liver fibrosis, which may be pathophysiologically explained by the fact that activated hepatic stellate cells (HSCs) express FAP and are thought to play an essential role in promoting fibrosis in the liver. Here, FAP is linked to Hepatic fibrosis.