Having determined that NTA-tau and p-tau levels increase in the plasma of HD patients as disease progresses, we next investigated the relationship between clinical features and tau by performing Spearman correlations between plasma tau measurements and TFC, cUHDRS, the Mini-Mental State Examination score (MMSE), and the Addenbrooke’s cognitive rating scale-revised score (ACE-R) (Fig. 1). Here, MAPT is linked to Huntington disease.