Interestingly, 16 out of 33 enrolled patients (48.5%) were found to have underlying causes of DNA-RD, including 8(50.0%) patients with FA, 6(37.5%) with DSBD due to homozygous variant in NHEJ1 gene, and 2 (12.5%) BRCA2 carriers. Here, NHEJ1 is linked to Friedreich ataxia.