A recent study analyzed germline exomes from two MM cohorts (895 and 786 individuals) revealed that MM patients are more likely than (134,187) healthy individuals to carry pathogenic germline variants (PGVs) in BRCA1 (OR = 3.9) and BRCA2 (OR = 7.0) genes, which significantly increase cancer risk. Here, BRCA2 is linked to Miyoshi myopathy.