Several genes, including tumor protein p53 (TP53), mismatch repair genes, breast cancer genes (BRCA1, and BRCA2),and ataxia-telangiectasia mutated gene (ATM), have been implicated in the development of FHM and are associated with an increased susceptibility to various cancers [5–7]. This evidence concerns the gene TP53 and familial hemiplegic migraine.