Similarly, in liver cirrhosis, SPP1+ macrophages express markers such as TREM2, IL1B, LGALS3, CCR2, and TNFSF12,12 some of which—like LGALS3 and TREM2—are also observed in murine SPP1+ macrophages associated with dystrophic conditions.4 The gene discussed is SPP1; the disease is cirrhosis of liver.