GLI1 and lung adenocarcinoma: Interestingly, several known regulators of lung adenocarcinoma such as Gli1, a canonical downstream effector of the Hedgehog signaling pathway, βIII tubulin (Tubb3), and CC Chemokine Receptor 1 (Ccr1) were found to be significantly downregulated following Msi2 inhibition as well (Figure 5H; Rentas et al., 2016; Song et al., 2011; Han et al., 2017; Po et al., 2017; Avis et al., 1996; Wang et al., 2009a; Wang et al., 2009b; Stallings-Mann et al., 2012; McCarroll et al., 2015).