After adding Cycloheximide (CHX), a biochemical protein synthesis inhibitor, we observed that the degradation rate of CCT6A significantly decreased following TRIM38 knockdown and markedly increased upon TRIM38 overexpression in CRC cells, suggesting that TRIM38 facilitated the degradation of CCT6A (Figure 5E,F). The gene discussed is TRIM38; the disease is colorectal carcinoma.