DNA methylation is a prevalent chemical modification wherein specific bases within a DNA sequence undergo methylation catalyzed by DNA methyltransferase (DNMT), mainly targeting CpG islands in gene expression regulatory elements.[35] Abnormal CpG methylation reportedly results in the silencing of tumor‐suppressor genes and the activation of oncogenes, which are intricately linked to tumorigenesis and cancer progression.[36, 37] Based on website and bioinformatics data analysis, we identified the potential methylation of CpG islands in the promoter region of TRIM38. This evidence concerns the gene DNMT1 and cancer.