The protective effect of tubule‐specific ATG5 ablation in AAN mice and uIRI mice also manifested in the reduction of α‐SMA, collagen I, collagen III, and upregulation of AQP1, OAT1, and Na+/K+‐ATPase (Figure 3L,M; Figure S6D,E, Supporting Information). This evidence concerns the gene ATG5 and Balkan nephropathy.