found that CDC20‐mediated PHD3 ubiquitination prevents the interaction between VHL and HIF‐1α in liver cancer, thereby preventing it from VHL‐mediated degradation and leading to increased stability and activity of the HIF‐1α protein.[38] CDC20+KIF20A+PTTG1+ cell subpopulation showed the highest hypoxia status among other cells in glioma according to the single‐cell atlas. This evidence concerns the gene EGLN3 and central nervous system cancer.