TNF and aging: Gendrisch F et al. (23) studied regulators of skin aging and inflammation, It was found that lutetin can inhibit skin aging and promote wound healing by inhibiting pro-inflammatory factors IL-1β, IL-6, IL-8, IL-17, IL-22, TNF-α, COX-2 and regulating NF-κB, JAK–STAT, TLR signaling pathways.