Therefore, we conducted a comprehensive evaluation of the association between ALDH2 rs671 and diabetes using standardized clinical diagnostic criteria, including glycosylated hemoglobin A1c (HbA1c), fasting plasma glucose (FPG), postprandial 2-h plasma glucose (P2hPG), and prior diagnosis, while adjusting for potential confounding factors. This evidence concerns the gene ALDH2 and diabetes mellitus.