Age of drinking onset, which ranged in AUD individuals from 14 to 20 years of age, was negatively correlated with Rage (r = −0.61, p = 0.012, Pearson’s r), Tlr4 (r = −0.53, p = 0.035, Pearson’s r), Iba-1+IR (r = −0.63, p = 0.005, Pearson’s r), CD68+IR (r = −0.88, p = 0.00003, Pearson’s r), and Aβ1–42+IR (r = −0.80, p = 0.0002, Pearson’s r), and positively correlated with expression of ChAT (r = 0.49, p = 0.032, Pearson’s r), suggesting that a younger age of drinking onset is associated with increased AD-associated neuropathology in the adult basal forebrain. Here, TLR4 is linked to Alzheimer disease.