Expression levels of the HMGB1 receptors RAGE and TLR4 are also increased in the post-mortem human brain of individuals with AD and positively correlated with severity of brain pathology (Lue et al., 2001; Donahue et al., 2006; Walter et al., 2007; Miron et al., 2018). This evidence concerns the gene AGER and Alzheimer disease.