HMGB1 and Alzheimer disease: Given the commonalities in neuropathology observed across models of human adolescent binge ethanol exposure and AD, we sought to test the hypothesis that adolescent binge drinking increases AD-associated neuropathology in adulthood through proinflammatory HMGB1 signaling in the post-mortem human AUD basal forebrain and in the 5xFAD mouse model of AD.