Variables such as age, sex, BMI, NYHA class, EF, PH, prolonged QTc, NT-proBNP, SUA, ALB, TyG index, hyponatremia, eGFR, ACEIs/ARBs/ARNIs, B blockers, MRAs, and SGLT2is were considered when conducting the subgroup analyses. The gene discussed is NPPB; the disease is Hyponatremia.