Using the LASSO regression model, 16 variables (sex, age, BMI, LVM, PH, prolonged QTc, LVM, NT-proBNP, SUA, TyG index, hyponatremia, eGFR, ACEI/ARB/ARNI, B blocker, MRA, and SGLT2i) were identified from the cohort, with nine of these ultimately selected to be included in the basic model (Supplementary Table S2 and Supplementary Figures S1A,B). This evidence concerns the gene NPPB and Hyponatremia.