A study (Jian et al., 2024) clarified that isorhamnetin markedly upregulated SLPI to inhibit the Mincle/Syk/NF-κB signaling pathway, which diminished M1 macrophage differentiation while facilitating M2 macrophage differentiation to attenuate AKI-triggered renal inflammatory reactions. Here, SLPI is linked to acute kidney injury.