SIRT1 and acute kidney injury: Within kidney disease research, studies indicate that quercetin exhibits protective capabilities against radiation-induced DNA damage and kidney cell death (Özyurt et al., 2014; Zhang N. et al., 2024), while simultaneously mitigating AKI via inflammatory suppression and enhancement of antioxidant systems and SIRT1 (Khajevand-Khazaei et al., 2018).