This also implies that their downregulation can affect tumor cell proliferation; Strong selective genes include ERBB2, CD19, EGFR, CD22, CD79b, PSMA, Claudin-18.2, MET, ERBB3, NaPi2b, DLL3, AXL, CD25, CD46, CD74, CDH6, ROR1, ALCAM, CCR7, CD117, CD44, DLK-1, EPHA5, FGFR2, FGFR3, FLT3, GPR20, HAVCR1, IGF1R, LIV-1, PTK7, SLAMF7, SLC44A4, TDGF1 and A2aR, they exhibit significant dependence in specific cellular contexts. Here, CD22 is linked to neoplasm.