Recognizing the role of the glymphatic system and its connection with cerebral lymphatic drainage, which functions as a clearance system for amyloid, tau, and other brain metabolic waste (Rasmussen et al., 2018, Reeves et al., 2020), clinical conditions such as chronic hydrocephalus or NPH may pose a significant risk for the progression of various neurodegenerative diseases, including Alzheimer’s disease. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.