demonstrated experimentally that the loss of the hypoxia-driven splicing regulator ESRP1 leads to the skipping of hMENA exon 11a, resulting in the production of the pro-metastatic isoform hMENAΔ11a, which promotes EMT through the TGF- RBFOX2-ESRP1 axis and facilitates breast cancer metastasis (93). This evidence concerns the gene RBFOX2 and breast carcinoma.