found through global correlation analysis of array-based comparative genomic hybridization (aCGH) data with clinical pathological information of GC from a large cohort and further validation using a large independent cohort, that copy number gains in three chromosomal regions, 8q22 (including ESRP1 and CCNE2), 8q24 (including MYC and TNFRSF11B), and 20q11-q13 (including SRC, MMP9, and CSE1L), lead to poorer patient survival. The gene discussed is ESRP1; the disease is gastric cancer.