Through experimental validation, it was found that cells overexpressing lncRNA CCAT2 promote the transformation of CD44 from its standard form to variant CD44 isoform 6 (CD44v6) by regulating the alternative splicing of CD44, and a high expression of CD44v6 is associated with more severe lymph node invasion, later T staging, and worse prognosis in gastric cancer patients. Here, CD44 is linked to gastric cancer.