CTCF and clear cell renal carcinoma: reported that overexpression of circESRP1 downregulates c-Myc, a crucial oncogene involved in tumor development, through the CTCF-dependent positive feedback loop circESRP1/miR-3942/CTCF-mediated EMT pathway, thereby reducing the migration and invasion capabilities of ccRCC cells and inhibiting the progression of clear cell renal cell carcinoma both in vitro and in vivo (70).