reported that overexpression of circESRP1 downregulates c-Myc, a crucial oncogene involved in tumor development, through the CTCF-dependent positive feedback loop circESRP1/miR-3942/CTCF-mediated EMT pathway, thereby reducing the migration and invasion capabilities of ccRCC cells and inhibiting the progression of clear cell renal cell carcinoma both in vitro and in vivo (70). This evidence concerns the gene CTCF and neoplasm.