The SHAP summary plot highlighted the following risk factors for bone metastasis (BM) in prostate cancer, ordered by their importance: Radscore (higher), Gleason Score (higher), pathological tumor volume (larger), elevated ALP levels, elevated postoperative PSA, elevated preoperative PSA, and extracapsular extension (ECE) invasion of the tumor (Figures 8A, B). The gene discussed is KLK3; the disease is prostate cancer.