The SHAP summary plot highlighted the following risk factors for bone metastasis (BM) in prostate cancer, ordered by their importance: Radscore (higher), Gleason Score (higher), pathological tumor volume (larger), elevated ALP levels, elevated postoperative PSA, elevated preoperative PSA, and extracapsular extension (ECE) invasion of the tumor (Figures 8A, B). This evidence concerns the gene KLK3 and prostate carcinoma.