KLK3 and Familial prostate cancer: The SHAP summary plot highlighted the following risk factors for bone metastasis (BM) in prostate cancer, ordered by their importance: Radscore (higher), Gleason Score (higher), pathological tumor volume (larger), elevated ALP levels, elevated postoperative PSA, elevated preoperative PSA, and extracapsular extension (ECE) invasion of the tumor (Figures 8A, B).