Germline 9p21.3 deletions involving the contiguous CDKN2A/CDKN2B/ANRIL region exhibit cancer predisposition syndrome with characteristics overlapping NF1, familial atypical multiple mole melanoma syndrome (FAMMM), and Li–Fraumeni syndrome (LFS) (7, 8). The gene discussed is CDKN2B; the disease is Li-Fraumeni syndrome.