Germline 9p21.3 deletions involving the contiguous CDKN2A/CDKN2B/ANRIL region exhibit cancer predisposition syndrome with characteristics overlapping NF1, familial atypical multiple mole melanoma syndrome (FAMMM), and Li–Fraumeni syndrome (LFS) (7, 8). This evidence concerns the gene CDKN2B and familial atypical multiple mole melanoma syndrome.