An Iraqi case with 1.7-Mb deletion involving FOCAD, IFN gene cluster, MTAP, CDKN2A, CDNK2A-DT, CDKN2B, and ANRIL had multiple malignancies including melanoma, extraskeletal osteosarcoma, lymphoepithelial carcinoma, low-grade myofibroblastic sarcoma, anaplastic pleomorphic xanthoastrocytoma, astrocytoma, and 16 benign or premalignant tumors (10), while the Italian case with a larger 2.135-Mb deletion presented with fewer tumors including melanomas, dysplastic nevi, and anaplastic astrocytoma (6). Here, CDKN2B-AS1 is linked to extraosseous osteosarcoma.