CDKN2B-AS1 and Li-Fraumeni syndrome: Germline 9p21.3 deletions involving the contiguous CDKN2A/CDKN2B/ANRIL region exhibit cancer predisposition syndrome with characteristics overlapping NF1, familial atypical multiple mole melanoma syndrome (FAMMM), and Li–Fraumeni syndrome (LFS) (7, 8).