discovered that targeting the JAK2/STAT3 signaling pathway resulted in decreased levels of IL-6, ICAM-1, Bcl2, and Bax in renal tissues of rats with STZ-induced DN, leading to a reduction in inflammatory response, apoptosis, mitigation of pathological damage to the kidneys, and enhancement of renal function (53). The gene discussed is IL6; the disease is liver dysplastic nodule.