There is clear evidence from genetic and animal studies that JMJD6 is a biologically important 2OG oxygenase.38,55,57 JMJD6 is linked to diseases and is a current medicinal chemistry target for prostate cancer.67 However, studies investigating its biochemical properties and the development of modulators for JMJD6 have been hampered by a lack of efficient assays measuring its catalysis. Here, JMJD6 is linked to prostate cancer.