LMNB1 and adult-onset autosomal dominant demyelinating leukodystrophy: The LMNB1 gene, situated at chromosome 5q23.2, encodes the protein laminB1.Overexpression of LMNB1 protein in ADLD has been associated with increased nuclear rigidity in fibroblasts and dysregulation of alternative RNA splicing, affecting RNA splicing processes (Ferrera et al., 2014; Bartoletti-Stella et al., 2015).