LMNB1 and adult-onset autosomal dominant demyelinating leukodystrophy: Adult-onset autosomal dominant leukodystrophy (ADLD) is a rare, slowly progressive, and fatal neurodegenerative disorder characterized by the loss of central nervous system (CNS) white matter (Neri et al., 2023), caused by either LMNB1 duplications or heterozygous deletions upstream of the LMNB1 promoter (Padiath et al., 2006; Giorgio et al., 2015).