There are potential opposite changes in hippocampal and reticulo-thalamic (RT) GABAergic parvalbumin (PV) interneurons, as well as differential expression of MAP2 and postsynaptic density protein-95 (PSD-95), which may form the basis of precursor local sleep disorders in the rat models of PD (Radovanovic et al., 2021). This evidence concerns the gene DLG4 and Parkinson disease.