TH and major depressive disorder: The use of GABAA antagonists can also effectively reduce the activation of microglia and astrocytes, increase the expression level of tyrosine hydroxylase (TH), and inhibit α-syn levels, finally improve motor incoordination and impaired locomotor gait, fatigue, anxiety, depression, and impaired short-term memory (Izquierdo-Altarejos et al., 2024).