FOXP4 and laryngotracheoesophageal cleft: Evidence from a genome-wide association study (GWAS) on individuals experiencing LC, which examined data from 6,450 LC cases and 1,093,995 population controls across 24 studies conducted in 16 countries (132), revealed that individuals carrying a specific single nucleotide polymorphism (SNP) in the FOXP4 gene (rs9367106) have a higher risk of developing LC.