The orphan testicular receptors (TR2/4, NR2C) are involved in the transcriptional regulation of metabolism,58,59 bone physiology,60 and neuronal development.61,62 TR2 is primarily expressed in the prostate, seminal vesicle, and testis, while TR4 exhibits a broader expression profile across the testis, prostate, ovary, cerebellum, and hippocampus.63,64 Dysregulation in TR2 and TR4 activity has been associated with a spectrum of cancers (prostate, breast, liver, pituitary corticotroph tumors)65–68 and enhanced tumor metastasis and progression.68 The gene discussed is NR2C2; the disease is cancer.