COUP-TF1 is essential for central nervous system development88 while COUP-TF2 acts as a crucial regulator of cell differentiation and angiogenesis, contributing to tissue homeostasis and maintenance.89–91 In cancer, COUP-TFs have various roles, with COUP-TF2 affecting angiogenesis and tumor growth.92 NR2F6 is also involved in carcinogenesis and correlates with poor prognosis in several cancer types.93–95 Additionally, the NR2F receptors are involved in metabolic regulation and immune system modulation, particularly in T-cell differentiation and function.96,97. The gene discussed is NR2F1; the disease is neoplasm.