Validation studies in a cellular reporter gene assay indicated TLX activation with EC50 values of 9.2 μM (14), 1.0 μM (15), and 250 nM (16) and 15 showed a trend toward SIRT and SLC1a1 but not p21 induction in human glioblastoma cells (T98G) in qRT-PCR experiments.141 Importantly, TLX expression was not affected by 15. Here, SLC1A1 is linked to glioblastoma.