SETD2 and diffuse large B-cell lymphoma: Another study using dogs with diffuse large B-cell lymphoma (DLBCL), which is the most common type in dogs, reported common mutations in 8 genes in more than 15% of the cases: TRAF3, SETD2, POT1, TP53, MYC, FBXW7, DDX3X, and TBL1XR128 genes (7).