AKT1 and neoplasm: We also summarized the signaling pathways involved in tumor aerobic glycolysis as well as in glycolysis in senescent cells and found that some signaling pathways in tumor cells also play a role in cellular senescence, such as the PI3K–AKT–mTOR pathway and the Ras signaling pathway, and can promote glycolysis in tumor cells, leading to increased tumor cell proliferation.