Our aim was to pinpoint studies that simultaneously addressed the issues of “aging” and “tumor.” There are only eight signaling pathways targeted by such studies, namely, the PI3K/mTOR, JAK–STAT, GH/IGF‐1, NF‐κB, Hippo, Wnt/β‐catenin, Notch, and AMPK signaling pathways; detailed data on completed and ongoing clinical trials are summarized in Table 1. Here, NFKB1 is linked to neoplasm.