In addition to the studies above investigating the direct role of microglia in the spread of pathological SOD1, there are a few studies suggesting that microglia might play a more indirect role in the spread of TDP-43, an RNA-binding protein that requires mislocalization from the nucleus to the cytoplasm to form aggregates.181 Several studies have previously shown that misfolded TDP-43 can propagate from cell to cell in a prion-like manner in amyotrophic lateral sclerosis,9,163,182 but few have mentioned the role of microglia in this regard. Here, TARDBP is linked to amyotrophic lateral sclerosis.