Furthermore, the finding that exosomes from microglia can carry misfolded SOD1 was not corroborated in the in vivo study by Silverman et al. 180 Thus, given the scant and conflicting data on this topic, further studies investigating whether misfolded SOD1 is present in microglial exosomes and whether it can also be transmitted between cells will be important to understand the role of microglia in the propagation of SOD1 in amyotrophic lateral sclerosis. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.