TRPC5 and kidney disorder: High TRPC6 expression is mainly found glomerular diseases.32 Dysregulation of glomerular ion channels, such as changes in TRPC6, can lead to devastating glomerular disorders; many channels, including TRPC6, TRPC5 and various ionotropic receptors, are promising targets for drug development, and our study demonstrates that the high expression of TRPC6 in meningiomas may impact renal disease.