Suppressing TNC expression through siRNA decreases glucose uptake and lactate production in the prostate cancer cell lines DU145, PC3, and LNCaP, while substantially decreasing the protein levels of the glycolytic enzymes HK2, LDHA, and pyruvate kinase isozyme M2 (PKM2) (Qian et al., 2022). This evidence concerns the gene HK2 and Familial prostate cancer.