IL2 and systemic sclerosis: Therefore, based on their cytokine and growth proangiogenic factor composition, BM-MSC-CM and WJ-MSC-CM might be employed to ameliorate vascularization of avascular skin areas (also known as desertification), to modulate altered immune responses through IL-10 and IL-2 secretion, and to halt fibrosis in SSc (Margiana et al., 2022; Yu et al., 2022).