After discovering that the induction of IGF-1 production activates a pathway related to chemotherapy resistance (PIK3/AKT) and transportation to lactate from inside the cell outside, favoring tumor growth, researches have tried to develop strategies to overcome this issue, by simple starvation (72 h fasting prior to chemotherapy) or through starvation mimetics (nutraceuticals, for example), which are the compound that blocks this pathway or others related to, as the SGLT-2, reducing glucose uptake by cancer cells (283, 284). Here, IGF1 is linked to cancer.