However, physical exercise has documented positive effects, including improved immunological function through increases in neutrophils, monocytes, T lymphocytes and macrophages; higher levels of immunoglobulins (IgA, IgM and IgG), crucial for lung infections; and regulation of C-reactive proteins levels, which are elevated in LC patients. The gene discussed is CD79A; the disease is laryngotracheoesophageal cleft.